Start hormone replacement early

Hormone replacement therapy, often taken by women who are experiencing the downsides of post-menopausal hormone change, has another effect: It seem to protect against dementia.

The important kicker, though, is that to get the most of that benefit it needs to be started early, according to a new study out of Weill Cornell Medicine. And by “early” they mean as soon as menopausal symptoms start, i.e., in perimenopause.

If that happens — if she starts taking them early and keeps going for 10 or more years — “there was a 26% reduced risk of dementia.”

Quoth the lead researcher:

“[I]n the right woman, at the right dose, and for the right duration of time, I believe that hormone replacement therapy can be one of our most powerful tools to reduce a woman’s risk for cognitive decline.”

Side note: What’s the difference between hormone therapy and hormone replacement therapy? Find a nice explanation right here.

Correction

Grr. We made a stupid mistake in Saturday’s edition, referring to osteoarthritis instead of osteoporosis. Despite a lot of work, we can’t even come up with a decent excuse.

Former smokers need cancer screening

New guidelines from the American Cancer Society suggest that more smokers and former smokers be screened for lung cancer, and that screening begin earlier.

The change from the ACS’s 2013 guidelines now say that anyone with a “≥20 pack-year smoking history” — i.e., about a pack a day — should consider an annual low-dose CT scan starting at age 50 instead of 55.

It doesn’t matter how long it’s been since they quit, either. The new recommendation would mean about 5 million additional Americans should get those scans.

Attention, pharmacy techs!

The last chance to get your GPhA immunization certificate is coming up! In other words, you really want to sign up for GPhA’s Immunization Delivery Training for Pharmacy Technicians.

In short, having this certificate on your résumé will help you stand out from your peers when it comes to looking your boss in the eye. (No offense, peers.) It’ll also help you sit for PTCB’s Advanced Skill Exam.

Help your career and maybe your bank account. Check out GPhA’s Immunization Delivery Training for Pharmacy Technicians — the live portion is Sunday, December 3.

Where’s the government when you need it?

Not happy with how private industry has responded to nationwide drug shortages, two high-ranking GOP representatives want answers from the FDA about why the government hasn’t done more.

They want the FDA to make it easier for domestic companies to get generic drugs into production, and they want the agency to find a way reduce America’s reliance on foreign-made medicine. (It’s not clear how reducing overseas drug imports would help alleviate the shortages.)

The problem, as FDA Commissioner Robert Califf pointed out, is that there’s little incentive for domestic manufacturing of generic drugs. “[W]e essentially have two drug industries in the US,” he said in August.

He cited an “innovator industry” of branded drugs where “the prices are too high,” and the generics industry, where “a lot of the prices are too low.”

And there’s little the FDA can do. As the director of the its Oncology Center of Excellence pointed out, the agency can’t require a company to manufacture a drug or even report spikes in demand. And, of course, even streamlining the approval process won’t help if there’s not enough incentive for a domestic company to make the drug.

Virus-checking arrivals

The CDC is going to be testing incoming travelers at four major airports^*, looking for respiratory viruses. It won’t stop people from entering the country, but it’s going to help the agency get a better handle on how Covid, the flu, and RSV are spreading and on any new variants beginning to spread. (It’s entirely voluntary.)

^* JFK, SFO, Boston’s Logan, and Washington’s Dulles airports

Spicy brain boost

People over 60 who consume 6-(Methylsulfinyl)hexyl isothiocyanate seem to have improved cognitive function.

How do you get 6-MSITC? From wasabi.

The study out of Japan’s Tohoku University was a small one — 72 people aged 60+ over 12 weeks. Interestingly, the ‘wasabi’ group was given tablets, so they didn’t get to enjoy the full effect of 100 mg of wasabi^*. Still…

At the end of the experiment, those who had ingested wasabi tablets showed significantly better performance in their episodic memory (recalling events from the past) and working memory (holding information temporarily) based on a series of cognitive tests.

^* About 1/16th of a teaspoon or 1.25 Wilhelm screams 

Reversing osteoporosis?

Aussie researchers say they’ve found a way to reverse osteoporosis. You might think of it as a “wear and tear” condition, they say, but that doesn’t account for 21st century medicine.

What they found was a type of stem cell (called Gremlin 1 cells) in joint cartilage that — when there are enough of them — will lead to “significant recovery of cartilage thickness and reduced osteoarthritis.”

So the Aussies treated those cells with a growth factor (FGF18, or Sprifermin to its friends) and got them back in action, leading to repaired cartilage … and the end of osteoporosis.

“The findings of our study reimagine osteoarthritis not as a ‘wear and tear’ condition but as an active, and pharmaceutically reversible loss of critical articular cartilage stem cells.”

They’re currently in a phase 3 trial of Sprifermin “and researchers envision public access to this treatment soon.”

Fingerprinting pills

Here’s a new idea for finding counterfeit meds: Use the surface of each tablet as a tiny QR code. That’s what German researchers did with a technology they call SmartID^*.

The idea is that every tablet or capsule has a unique surface thanks to the normal manufacturing process. SmartID involves scanning that surface to read its “fingerprint” and creating a barcode that matches it.

The SmartID app developed as part of the project is then used to check whether the information stored in the barcode matches the data captured from the surface texture.

Making counterfeit pills isn’t difficult, but making them with the identical texture as the real deal? Not gonna happen.

^* To be fair, that’s a bit generic, isn’t it? You would think they’d come up with something like “PillID.”

Salt and diabetes

It’s not just too much sugar that can raise your diabetes risk. Apparently too much salt can, too.

Using data on more than 400,000 Brits over almost 12 years, researchers from Tulane University found that the more often people reported using salt — “sometimes,” “usually,” or “always” — the greater the risk of developing type 2 diabetes. The most-frequent salt users had a 39% higher risk.

Why? They don’t know for sure, although they speculate that salt makes food taste better, encouraging people to eat more of it. If you’ve ever had British food, this makes a lot of sense.

Happy pills?

Being on the capital-P Pill has — anecdotally at least — been associated with depression. But now a team of UK and US researchers have found the opposite is true.

Analyzing data from more than 6,200 US women from 18–55, they found that contraceptive pill users were less than half as likely to suffer from major depression as former users.

Why? Could be a bunch of reasons. Less anxiety. “Survivorship bias,” where depressed people stopped taking it. Or maybe just more fun times.

^* For their part, the Brits analysed.

Insulin isn’t so sensitive

Today’s fun fact, brought to you by British researchers, is that insulin can last a lot longer at room temperature than you might think.

[I]t was found that unopened vials and cartridges of certain types of insulin can be stored at up to 25 degrees Celsius (77 degrees Fahrenheit) for up to six months.

Additionally, they can be held at 37 degrees Celsius (98.6 degrees Fahrenheit) for up to two months.

And when the temperature fluctuates — say, between 77°F and 99°F — it could last up to three months “without any significant decline in insulin activity.”

Small caveat: This may not apply to insulin pumps. They didn’t have data to check.

Childhood diseases becoming resistant

Antibiotic overuse continues to come home to roost: Aussie researchers have found that there are now “Alarmingly high rates of bacterial resistance” to the meds commonly used for childhood illnesses.

[M]any antibiotics recommended by the World Health Organization had less than 50 percent effectiveness in treating childhood infections such as pneumonia, sepsis, and meningitis.

Two examples: Ceftriaxone is now only about 33% effective against sepsis or meningitis, and gentamicin is only about 50% effective against sepsis and meningitis.

The study was limited to the Asia-Pacific region, but it’s unlikely the problem will be that limited.

IBD infection risk

When someone has inflammatory bowel disease, they’re at increased risk of infection — that’s not news. But Swedish researchers found that “This is also true for patients who appear to have low-active disease in clinical terms, but who have microscopic intestinal inflammation beneath the surface.”

In other words, unless their intestines are fully healed there’s a higher risk of sepsis and other infections that require hospitalizations — a 59% higher risk, in fact. So simply going by “My meds made me feel better” might not be enough.

A small correction

Yesterday’s article “Ozempic freak-out” mistakenly left out the link to the source — it explained how companies and stock holders are (over?) assuming how much weight loss is going to affect consumer behavior. You can read that source here.

Another odd Ozempic side effect

How about social anxiety? Who would have expected that when overweight people slimmed down, suddenly more people started talking to them? For folks used to being on the sidelines, the renewed attention can be stressful even when it’s just a bunch more “Hi, how are you”s.

“When attention shifts from negative attention (jeers, dirty looks, rude comments, being ignored) to positive attention (compliments, flirting, offering connection or support, etc.), it may feel like unfamiliar territory.”

Delicious heart medicine

It’s called tongxinluo. It includes “seven herbs and animals including cockroach, scorpion, cicada, centipede, and leech” and sometimes — seriously — frankincense and myrrh. In traditional Chinese medicine, it’s used to to treat patients after a heart attack or stroke, and it was approved for that in China in 1996.

And, now, after a “large-scale, Western-style clinical trial” of more than 3,700 patients, University of Texas researchers say it actually works, and pretty well:

Results showed major adverse cardiac and cerebrovascular events were about 30% lower in the group that took tongxinluo compared with those taking the placebo at 30 days. These benefits persisted for one year after discharge.

Why does it work? They don’t know, and with so many ingredients and combinations it might take some work to find out. In the meantime you’ll have to use your blender.

A better melanin than melanin

Natural melanin can protect against skin cancer by scavenging up free radicals caused by sun exposure. But you know what it’s missing? Nanotechnology. So material scientists at Northwestern came to the rescue, creating a synthetic melanin they say is better than the real stuff for healing skin.

“It’s like super melanin. It’s biocompatible, degradable, nontoxic and clear when rubbed onto the skin. In our studies, it acts as an efficient sponge, removing damaging factors and protecting the skin.”

Not only could it be used as a treatment, it can also prevent sun damage by, say, being added to sunscreen. Not enough? It can also protect people from “heavy metals and toxins, particularly nerve gas.” No word on whether it’s also a dessert topping.

Cannabis fungi danger

Fungi really like cannabis. You can find more than 100 species on the plant, from the roots to the buds, yet none of the states that have legalized it in any form require any kind of testing to see if those fungi are dangerous.

Much ado about nothing? Consider this: A 2020 study “revealed cannabis users are 3.5 times more likely to develop a fungal infection compared to non-users.” (A 2019 study found the vast majority of infections came from smoking, not edibles, if you’re curious.)

Cannabis use is associated with fungal infections in kidney transplant patients and an increased risk of pneumonia, which can be triggered by fungal infections, too.

And if we’ve learned anything from the HBO documentary “The Last of Us,” it’s not to mess with fungi.

Note: Not a single “fun guy” joke. You’re welcome.

Infant mortality nudges up

ICYMI: The US infant mortality rate went up for the first time in two decades, according to National Center for Health Statistics data. From 2021 to 2022 the overall rate went up 3%, the first “statistically significant jump” since 2002.

Georgia was one of four states — the others being Iowa, Missouri, and Texas — with the largest increases.

Georgia health officials said they are working to understand infant mortality trends in that state, and noted the 2022 rate was similar to rates in 2018 and 2019.

Of the 38 highest-income countries (that make up the OECD^*), the US ranks #33 — better than Chile but worse than Slovakia.

^* Organisation for Economic Co-operation and Development

Stick with the landline, guys

How’s this for a lede: “Men who use their cell phones frequently have lower sperm counts than men who don’t”? Scary stuff.

[M]en who used their phones 20 or more times a day had a 21% higher risk of having a low overall sperm count that fell below the World Health Organization’s reference values for fertile men.

Interesting tidbit 1: It doesn’t seem to matter where the guys carry the phones (pants, jacket, belt), and they aren’t sure if how the phone is used — e.g., voice, texting, browsing — makes a difference.

Interesting tidbit 2: The effect has lessened with newer technology. Second-generation (2G) phones were worse than 3G, and 3G was worse than 4G. So there’s an argument for upgrading if you’re still nursing along your Pixel 1.

Next up: Trying to find the mechanism that’s at work (could it be heat?) and how specific phone usage affects the little swimmers.

Open enrollment is open

Remember that open enrollment for Obamacare marketplace plans started yesterday and runs through January 15. Last year more than 16.5 million Americans signed up for coverage, and this year is expected to be bigger thanks to millions being removed from Medicaid.

The good news is that people who find themselves kicked out of Medicaid can sign up for a marketplace plan at any time, in or out of the official enrollment season.

And while premiums have increased for a lot of plans, most people will qualify for a subsidy. They’re also likely to qualify for a lot of other cost savings if they earn less than about $75,000 for a family of four or $36,450 for an individual.

How insulin can lead to pancreatic cancer

Too much insulin — in the case of type 2 diabetes, for example — can lead to pancreatic cancer. This isn’t one of those “is associated with” findings; Canadian researchers actually found the cause and effect.

In a nutshell, it’s a case of too much of a good thing. Normal insulin levels stimulate the pancreas’s acinar cells to hum along, producing digestive juices. But too much insulin overstimulates them, leading to inflammation. Inflammation, we know, is one of the two big causes of everything bad, and in this case it converts those normal cells into precancerous ones.

So that’s a message for patients with type 2 diabetes: They’re risking more than they might think.

An AIP thanks — take 2

It seems that lots of you don’t use Facebook anymore, so you might have missed AIP VP Jonathan Marquess’s shout-out and thanks to all the AIP members who attended the fall meeting in Peachtree City.

So here’s the best part — photos from the event! (Click any one to embiggenate.)

Ozempic freak-out

The market’s knees are jerking like a patient with restless leg syndrome after slamming a couple of Red Bulls. The cause: Ozempic and kin, which are (they think) going to totally change the world.

Beer and snack stocks are plummeting. Walmart said it’s taken a hit on food sales. Clothing brands could see a boost from slimmed-down shoppers eager to update their wardrobes. Airlines are already calculating how much lighter flyers will save them on fuel costs.

Considering how new these drugs are, how expensive they are, and the fact that they have to be taken for life, perhaps this is a bit of an overreaction. (As one analyst put it, “The market is in a shoot-first, ask-questions-later mood when it comes to weight-loss drugs.”)

Get those lozenges ready

Strep throat is on the rise — in some areas (like Florida), rates are more than double what they were last year, and in others there’s been a 400% jump. And that’s just the cases that have been reported.

The cause: Epidemiologists aren’t sure, but it might simply be that the pandemic shuffled all the usual seasonality of viruses. Or made people more susceptible. Or maybe Mercury is just in retrograde.

The problem: Regardless of the cause, pediatric amoxicillin is in shortage. That means either using a second-best antibiotic, or leaving the kids to recover on their own, spreading their germs all the while.

There really is a 5-second rule

When it comes to breathing in someone’s viruses, it seems that five seconds is ‘peak droplet’.

Using a mannequin and a particle-tracking velocimetry system (as one does), Japanese researchers measured the aerosol coming out of someone’s mouth — someone who’s (theoretically) infected with a virus.

Result: “[W]ith or without ventilation, the number of aerosol particles peaked within 5 seconds after face-to-face encounters and then declined rapidly.” It also didn’t matter whether the person (or, rather, the mannequin) was walking, jogging, running, or sprinting; the five-second rule was always in effect.

Their suggestions: Holding your breath, keeping a good distance, or “positioning oneself upwind.”

Fentanyl babies

Mothers who use fentanyl during pregnancy are having children with distinct physical features, and some of them are serious … and disturbing.

[T]he infants all had small heads, short stature, and distinctive facial features. Multiple infants had cleft palate, “rocker bottom” feet, and malformed genital organs. Other common features included short, broad thumbs, a single palmar crease, and fused toes.

Another other reason to get vaccinated

Here’s a surprise: “people who are vaccinated have a significantly lower risk of Alzheimer’s disease.” And by “vaccinated” they don’t mean against Covid or the flu. They mean vaccinated against anything.

First (a year ago) a University of Texas study found this applied to the flu vaccine. But then the same researchers expanded to see the effect of the Tdap, shingles, and pneumococcus vaccines, crunching the records of 1.65 million people over 65.

Remarkably, all 3 of the vaccines showed similar and quite significant benefits against Alzheimer’s disease. In an 8-year follow-up period, the risk of Alzheimer’s was 30% lower (7.2% versus 10.2%) in patients who had the Tdap vaccine versus those who hadn’t. For the shingles vaccine, the reduction in risk was 25%, 8.1% versus 10.7%. And for the pneumococcal vaccine, the risk was 27% lower, 7.9% versus 10.9%.

Holy wow — a 30% lower risk just from a routine vaccination. What’s weird is that the effect (at least for the flu shot) only comes from vaccination, not from infection.

Why is this happening? They’re still working to figure out the mechanism, but they think “that vaccines might work to protect against Alzheimer’s by ‘long-term reprogramming of innate immune cells,’ also called ‘trained immunity”.’

A pineapple’s worth

Like most people, you’ve probably laid awake at night wondering, “How much does the immune system weigh?” You can sleep soundly now as Israeli scientists have the answer: It weighs about as much as a pineapple (or six hamsters^*, as Science Alert points out).

^* Also 240 paperclips or 24 AA batteries

Icodec vs degludec

When the smoke cleared from the cage match between weekly (icodec) and daily (degludec) insulin injections, it was just about a draw — that’s according to British researchers who led a 12-country study of 582 people with type 1 diabetes.

“What we have found is that once-weekly icodec injections showed non inferiority to once-daily injections of degludec in reducing HbA1C after 26 weeks. Although there is a slightly higher rate of hypoglycaemia under this regime, we found this could be easily managed.”

Potential caveat: “Funding for this trial was provided by Novo Nordisk.”

AI designs new gastric acid treatment

We know that the gastric proton pump is responsible for excess stomach acid, and that existing proton-pump inhibitors come with some serious side effects. So Japanese scientists asked an AI to design a molecule that would bind to the proton pump and stop it from over-pumping.

The AI came up with a bunch of weird molecules, and the team synthesized the ones they thought looked most promising. The sixth one (“DQ-06”) worked. Then the humans stepped in and tweaked it to create “DQ-18,” a version that works better than the gastric acid inhibitor they were comparing these compounds to.

Obviously this is all in the lab, but it’s a real (potential) drug with a structure humans would likely not have come up with.

“I was skeptical when I saw some of the strange chemical structures, including DQ-02 (the second one they tested) and related ones,” said one researcher. “But we suspected there must be a reason AI suggests such strange chemicals.”

Breast cancer breakthrough

A group of pharmacology researchers, including some from Georgia Tech and Emory University, have figured out how breast cancers metastasizes. It’s a totally new mechanism, and it opens the door to treatment.

What they found: A protein called dynein is what powers the cancer cells through the soft tissue. Stop the dynein, stop the metastasis.

“[W]e found that dynein is extremely important for cell locomotion, which suggests a whole new method for cancer management. Instead of killing the cancer cells with radiation or chemotherapy, we are showing how to paralyze them.”

As for how to stop the dynein — that’s still up in the air.

Glioblastoma force multiplier

Cerebrospinal fluid is useful stuff, protecting the brain and all that. But it has a dark side: It can make glioblastoma cells more resistant to ferroptosis, which is how chemo/radiation therapy kills the cancer.

Draining the cerebrospinal fluid is a bad idea, obviously, but Aussie scientists found a possible solution: trifluoperazine, the 70+ year old anti-anxiety drug. It seems to “resensitize” the glioblastoma cells, allowing the therapy to work better.

Next up: Human trials, made easier because trifluoperazine has been considered safe and effective since the 1950s.

Kinda big eye drop warning

In case you missed it: The FDA has issued a warning about 26 (!) OTC eye drops because of the risk of infection “that could result in partial vision loss or blindness.”

The factory that made them not only had insanitary conditions, but product testing found actual contamination. The brands:

• CVS Health
• Leader (Cardinal Health)
• Rugby (Cardinal Health)
• Rite Aid
• Target Up&Up
• Velocity Pharma

The details and full descriptions are here.

Fighting bipolar meds’ side effects

Weight gain is a common side effect for kids taking meds for bipolar disorders, but University of Cincinnati researchers have found a simple potential solution: metformin.

The typical approach to weight gain has been to tell the kids, “Hey, we’ve treated your bipolar issues. Deal with the weight on your own.” So the UC folks wanted to see if metformin might help; psychiatrists are iffy about prescribing it, but a study might change their minds.

After two years and almost 1,600 kids across 60 sites they found … it works. A bit.

[M]etformin had a modest but significant effect at preventing and in some cases reversing weight gain in the study’s patient population. The drug was also found to be safe, with some gastrointestinal distress symptoms being the only side effects reported.

They weren’t expecting a miracle drug, but the results showed it’s likely worthwhile to consider metformin to help patients deal with the weight gain.

Another virus type to worry about

You can almost picture the editors at the Atlantic (World’s Most Depressing Magazine™) looking for something else to fret over.

Kudos to them for finding a new angle: “Whether it begins next week, next year, or next decade, another pandemic is on its way,” writer Katherine Wu explains. But rather than a new flu or coronavirus, we need to be worried about paramyxoviruses, even if they’re less of a threat^*. Because they’ve been lurking in the background, waiting for their chance to strike — when we’re not expecting it.

[L]ike flu viruses and coronaviruses, paramyxoviruses are found in a wide range of animals; more are being discovered wherever researchers look.

(But if we are expecting it, that removes one of its greatest weapons: Surprise. That leaves fear and ruthless efficiency. We shall see.)

^* Although measles, one paramyxovirus, is “literally the most transmittable human virus on the planet.”

Third strike (they’re out)

Some CVS and Walgreens pharmacists are — as you read this — in the second day of a three-day strike. “The walkout, which the organizers have dubbed ‘Pharmageddon’, is the third strike by pharmacists in a little over one month.”

And remember to share your experience:

A viable ketamine study

One trouble researchers have had with studies of ketamine is that it’s hard to have a control group; people can tell if they’ve been given the drug. But Stanford researchers not only found a workaround, they also found that ketamine (or rather the lack of it) can have a strong placebo effect.

They studied patients with depression who were also about to have surgery under general anesthesia. While they were unconscious, some were given ketamine, some a placebo. (It was triple-blind: Neither the researchers, the patients, or the surgeons knew who got what.)

End result: “The researchers were amazed to find that both groups experienced the large improvement in depression symptoms usually seen with ketamine.”

Said the senior author:

“I was very surprised to see this result, especially having talked to some of those patients who said ‘My life is changed, I’ve never felt this way before,’ but they were in the placebo group.”

What does this mean? As a co-author put it, “Now all the interpretations happen.”

Instant STD test

Penn State researchers have developed a virtually instant test for two major STDs. They use the same tech as rapid Covid tests (but don’t involve swabbing the nose) and can ID chlamydia and gonorrhea with 100% accuracy in two minutes.

They also say their test tech, which can detect pathogens’ genetic signature, can be tweaked to react to other diseases. As always, more research is needed.

Snake oil, 2023-style

It’s sad but not surprising: There are clinics out there offering treatments for long Covid that just don’t work. We’re not talking silliness like horse dewormer or scented candles — they’re touting stem cell therapy and exosome treatments even though there’s no evidence they work. But they sure cost a bundle*.

The UC Irvine researchers were curious how snake-oil salesmen were adapting to Covid. And just like Dr. Montague’s Cure-All can treat rheumatism, baldness, night sweats, hangnails, and all that ails you, apparently these therapies can now treat Covid-19. They’re being offered mostly in the US and Mexico, but also around the world.

“Of the 38 businesses, 36 of them marketed stem cell and exosome products as treatments for long Covid, six advertised them as ‘immune boosters,’ five claimed they treated patients in the acute infection phase, and two claimed the products they sold were preventive in nature.”

If you question the treatments, of course, you’re just yet another sheep and a pawn of Big Pharma, yada yada yada.

^* From $2,950 to $25,000, with the average being $11,322.

Diabetes danger with common drugs

Two common types of drugs — antipsychotics like haloperidol and antibiotics like fluoroquinolones — have a scary risk for people with type 2 diabetes: They can cause sudden cardiac arrest even in people with no history of cardiovascular disease.

And it’s apparently not just a slight difference.

People with type 2 diabetes who do not have a history of CVD have almost three times the risk of SCA if they take antipsychotic medications and nearly double the risk if they take certain antibiotics that prolong the QT interval, notably, macrolides and fluoroquinolones.

One of the Dutch researchers who discovered this displayed some British understatement when he said, “Perhaps these drugs could be avoided in some cases, and GPs should be more aware of the possible consequences of their use.” Indeed.

Witness the power of this fully armed and operational pharmacy and health sciences center

Mercer’s new 65,000-square-foot pharmacy and health sciences center is now open on the university’s Atlanta campus.

It contains some of the most cutting-edge lab technology found in any academic setting, adjustable classrooms to fit the needs of individual professors, and several areas for students to study and relax between classes.

The building is looking spiffy before all those students get their grubby paws all over it

Boning up on cannabinoids

If you have a mouse with a broken bone, you might try giving it a cannabinoid like CBD or its cousin, CBG. They seem to have a surprising ability: They not only relieve pain, they actually help the bones heal.

Penn State researchers were sorta expecting the pain relief, because there’s plenty of anecdotal evidence of that. But the bone healing caught them by surprise.

In the early phase of treatment, the cannabinoids were associated with an increase in the abundance of periosteal bone progenitors, which later develop into specialized bone cells that help bone tissue form. During the later phase of healing, CBD and CBG accelerated the process by which the body absorbs minerals to strengthen newly formed bone.

Money quote: “We still have a lot to learn about the biological mechanisms behind what we observed.”

Side note: Under no circumstances should you think about the fact that the researchers had to break the mice’s bones to do this study. Karma will take care of that.

Covid: What works, what doesn’t

Cutting to the chase: Statins like simvastatin have a significant benefit for critically ill Covid patients, but vitamin C does nada.

An international team of researchers studied more than 2,600 patients in 13 countries found that simvastatin …

… was shown to have a high probability (96%) of improving outcomes […] and a 92% chance of improving survival at 3 months. This equates to one life saved for every 33 patients treated with simvastatin.

And vitamin C? It was “ineffective and probably harmful^*.” Do they have a recommendation that includes a buzzword? You bet: “[T]he use of vitamin C in hospitalized COVID-19 patients should be de-adopted.”

^* This would have been sad news for Mom of Buzz, who always considered vitamin C a miracle drug.

Pharmacy chains pull back

The plan had been for the big pharmacy chains to dive headlong into primary care. But that’s just not working out thanks to issues like “financial woes, leadership shuffles, [and] staff shortages” and now they’re backpedaling big time.

The problems facing the three retail pharmacies are similar, and include rising drug prices, pressure from insurers, post-pandemic changes in customer behavior that have reduced store traffic, and an alarming spike in shoplifting.

The Long Read: Pharmacists’ Burnout edition

Why the strikes? Why the stress? USA Today has a great overview with “Prescription for disaster: America’s broken pharmacy system in revolt over burnout and errors”.

Pharmacists take an oath to hold patient safety in the highest regard when preparing and dispensing medication. But rising pressures inside the nation’s largest retail chains have forced pharmacists to choose between that oath and their job.

Sneezes: Let them out

If you’re going to sneeze and you’re tempted to hold it in, don’t.

Closing your mouth or nose during a sneeze increases the pressure in the airways five to 20 times more than a normal sneeze. With no escape, this pressure has to be transmitted elsewhere and that can damage your eyes, ears or blood vessels. Though the risk is low, brain aneurysm, ruptured throat and collapsed lung have been reported.

(What if you’re hiding from an axe murderer? Try pressing under your nose to stimulate the trigeminal nerves.)

Bad for the heart, good for the brain?

There’s apparently a link between higher levels of triglycerides and lower risk of dementia. That’s what Aussie researchers found when they parsed the data on more than 18,000 people over six years (average age 75). The higher someone’s triglyceride level, the lower their risk of dementia. (Which makes sense, as triglycerides are one of the brain’s main energy sources.)

Of course, this doesn’t mean one causes the other, just that there’s a link. And it doesn’t mean it’s time to load up on green eggs and ham, either. Even if there was a cause and effect, the high triglycerides come with their own set of problems, obviously.

Don’t stop thinking ’bout metformin

The article’s lede sums up the issue nicely: “Diabetes patients who stop using metformin are more likely to develop dementia.”

[R]esearchers found that patients who were prescribed metformin but stopped using it were 21% more likely to get a dementia diagnosis compared with patients who continued using metformin throughout their treatment.

The big issue, though, is that people don’t like taking metformin. The pill is big and the stomach issues can be an issue especially for people living in small apartments.

Quid pro quo

When oncologists get money from the pharma industry, they’re more likely to prescribe “non-recommended and low-value treatments.” That’s according to a group of cancer researchers and statisticians publishing in the British Medical Journal.

Docs prescribing meds from the companies that ‘take them to lunch’ isn’t new, but this is one of the first studies that looked at whether the meds were actually good for the patients. Um … nope.

One example:

The difference between the prescribing patterns of doctors was biggest for denosumab, a drug sold by Amgen as Xgeva, in castration-sensitive prostate cancer. U.S. guidelines recommend against the use of denosumab in the setting. Yet, 49.5% of patients whose doctors took pharma payments received the drug, compared to 31.4% of their counterparts whose oncologist hadn’t received payment.

And now a twist: When there was a choice between a brand-name drug and a generic, the docs who got more money were slightly more likely to prescribe the generic. So at least they’re trying to save the patients some money.

Short takes

“I ate what?”

“More than 7 million Americans unaware they have mild cognitive impairment.”

You can have my M&Ms when you pry them from my cold, dead fingers

“Foods like ice cream, chips and candy are just as addictive as cigarettes or heroin.”

Vaguely useful bipolar test

British researchers have developed a simple blood test that they say can … well, “diagnose” is a strong word. It can reveal biomarkers associated with bipolar disorder. Well, sort of. When they say it can help diagnose it, they mean the blood test alone has about a 30% chance of hitting the mark. When combined with a mental health assessment, though, it’s more useful.

Bottom line is that it’s more of a confirmation thing.

“Psychiatric assessments are highly effective, but the ability to diagnose bipolar disorder with a simple blood test could ensure that patients get the right treatment the first time and alleviate some of the pressures on medical professionals.”

The Long Read: The Future of Pharmacy edition

With another walkout planned at chain pharmacies, stress levels high while staffing is low, robotics and AI are coming to a pharmacy near you. Maybe.

The idea is to automate the repetitive tasks (and even help with issues like medication interactions) freeing pharmacists and pharmacy technicians for the more important work.

Bacteria for blood pressure

If you don’t make enough of a protein called ACE2, your body (and bodies of rats) will produce angiotensin II, a hormone that raises blood pressure. So how do you get more ACE2? By changing your gut bacteria, of course.

Researchers at the University of Toledo started with Lactobacillus paracasei (a friendly gut bacterium), engineered it to produce ACE2, and gave it to hypertensive rats with high blood pressure.

You’re expecting to read that it work, and it did, sort of.

[T]he blood-pressure-lowering effects were only seen in female rats. Though there was no difference in ACE2 expression between male and female rats, only the female rats saw a decrease in their blood pressure.

Why? Because, they think, “The gene encoding ACE2 is located in a region of the X-chromosome” that can sometimes be deactivated. The ladies have two copies of it, so they’ve got a backup. Regardless, they call the finding a steppingstone: “It is a real possibility that we can use bacteria to correct hypertension.”

Today’s Mercer shout-out

High-fives all around to Sharvari Kshirsagar, Sreelakshmi Menon, and Tanishka Saraf — three Mercer students who just took home half of the American Association of Indian Pharmaceutical Scientists’ annual Graduate Student Awards. W00t!

They politely sat in alphabetical order

For moms to be

Covid vax protection

When mom is vaccinated for Covid, Junior doesn’t just get protection from the virus, but also has a lower risk of a bunch of “poor outcomes” — notably NICU admission and death. That’s what Canadian researchers found when looking at the health data for more than 140,000 births in Ontario.

“Our results were consistent across the number of doses someone received during pregnancy, the trimester in which they were vaccinated, and the vaccine product they received.”

The right way to give insulin

Forget injections or even pumps. British researchers say that pregnant women with diabetes should all be using automatic insulin-delivery systems. Their study found that automatic, smartphone-based “hybrid closed-loop technology” technology for mom reduced a baby’s risk of “…premature birth, need for intensive care after birth, and being too large at birth, which increases the lifelong risk of overweight and obesity.”

“Compared to traditional insulin therapy methods, women who used the technology spent more time in the target range for pregnancy blood sugar levels — 68 percent vs 56 percent, which is equivalent to an additional two-and-a-half to three hours every day throughout pregnancy.”

Even better, they called the technology — wait for it — “game-changing.”

When OTC painkillers work just fine

When kids get “routine elbow surgery” (apparently that’s a thing), it’s tempting to give ’em opioids for the pain rather than deal with the whining. No need, say researchers at the Children’s Hospital of Philadelphia — ibuprofen and acetaminophen work just as well.

The researchers found no significant differences in pain ratings between opioid and non-opioid groups at any timepoint. Notably, 35% of patients who were prescribed opioids never took them, and 49% took only one to three doses over the entire postoperative period.

The study looked specifically at a procedure called closed reduction and percutaneous pinning (I see a few people in the audience nodding), but the docs say it might also apply to other orthopedic procedures.

RSV vax coming for younger folks

GSK reports AOK results for its RSV vax for people ages 50 to 59. It was a phase 3 trial, meaning the company is planning to submit final results to the FDA in hopes of having the shot approved for that age group — or at least people that age who are vulnerable to RSV.

The Long Read: The Cost of GLP-1s edition

GLP-1 drugs like Ozempic and Wegovy can save a lot of lives and a lot of money on healthcare, but they’re way too expensive for many of the people who could benefit. Or are they?

The New York Times explains how it’s more than just list price vs. actual price — there are plenty more reasons these drugs are going to be less expensive than we think.

Short Takes

States sue over social media

Georgia is one of 41 states (and DC) suing Facebook parent company Meta for ‘exploiting and manipulating’ children and playing a major role in the the ongoing youth mental health crisis.

Collectively, more than 40 states paint a picture of a company that brushed aside safety concerns about its products in order to addict as many young people as possible as a way of juicing its profits.

Add it to the list

“[A] flesh-eating parasite known as Leishmania mexicana is now likely spreading locally through some sand flies native to the southern U.S.”

DIY flu vax?

Patients may be able to give themselves the FluMist quadrivalent vaccine next year, if AstraZeneca’s request is approved by the FDA.

The company said it expects the FDA to decide on the vaccine by the first quarter of 2024, adding that it expects the vaccine to be made available for self-administration in the United States during the 2024-2025 flu season, if approved.

Diabetes treatment: The eyes have it

When you’re looking for a place to stick a device that help provide insulin, you probably wouldn’t think “in the eye.” That’s just what Swedish researchers did, though, and it wasn’t just because it sounds cool.

The miniature implants consist of a combo of insulin-producing islets of Langerhans and some electronic sensors, and they’re implanted between the iris and the cornea. Why there? First, the eye is “immune-privileged,” meaning it doesn’t have immune cells that will attack the device. Second, it’s easy for the Swedes to look into it (it being the eye and all) and see how the implant is doing.

The first tests on mice found that the implants work just fine for at least several months. It’s a proof of concept — now they want to see about adding the electronics to adjust the release of insulin as needed.

CDC: Ration the RSV vaccine

Due to shortages of the RSV vaccine — nirsevimab — the CDC is asking providers to ration their supply and only give the vaccine to the most vulnerable infants.

CDC recommends prioritizing available nirsevimab 100mg doses for infants at the highest risk for severe RSV disease: young infants (age <6 months) and infants with underlying conditions that place them at highest risk for severe RSV disease.

Captain Obvious is working overtime

Did they really need to do a study?

Drexel University released this bombshell: “Can We Trust Autism Information on TikTok? Not Always.”

[T]he research team concluded most of the information provided on TikTok appears to be misaligned with current clinical knowledge.

“Wearing an ‘I abuse drugs’ T-shirt” isn’t on the list

Canadian researchers have found a shocking list of “10 predictors linked to opioid overdose in chronic pain patients.”

• If they’re getting high-dose opioids
• If they’re getting fentanyl
• If they’re using multiple pharmacies
• If they’re using multiple prescribers
• If they have a substance use disorder
• If they have a history of opioid overdoses
• If they’re suffering from mental illness, depression, or bipolar disorder
• And the one that actually is worth noting: If they have pancreatitis

Get up and exercise

Who needs Daddy’s Little Helper? Apparently an effective alternative to Viagra is a bit of aerobic exercise^*. A new study in the Journal of Sexual Medicine …

…found that aerobic activities — such as walking or cycling – improved erectile function in all men with erectile dysfunction, regardless of body weight, overall health, or medication use.

And the worse the, er, problem, the more the exercise helped. On the standardized scale for this sort of thing, men with the biggest (?) issues reported an average improvement of 5 points with exercise and 4 to 8 points with Viagra or Cialis. So that’s pretty good.

This isn’t entirely new. Back in the Long Long Ago (2011), Nigerian researchers published a paper, “Effects of Aerobic Exercise in the Management of Erectile Dysfunction: A Meta Analysis Study on Randomized Controlled Trials” where they found the same thing.

^* “If I could get the aerobic exercise, I wouldn’t need the Viagra!” Ha ha.

Thanks, AIP members!

A big thank-you to all the AIP members who attended AIP’s fall meeting in Peachtree City! Check out some photos on AIP VP Jonathan Marquess’s Facebook post!

Safer bone marrow transplants … with potatoes

People who get a bone marrow transplant have a big risk of graft-versus-host disease (GCHD) — we’re talking 50%. You know what can help reduce that risk? The right gut bacteria.

Researchers from Baylor College of Medicine and the University of Michigan found that the gut biome changes after a bone marrow transplant, “and that this change contributes to GVHD aggravation.” Specifically, their levels of butyrate go down.

How do you get butyrate levels up? Potato starch. People can’t digest it directly, but a specific gut bacteria can — and it produces butyrate. So add a potato starch supplement, make the right bacteria happy, and reduce the risk from GVHD.

So far they’ve confirmed that taking a supplement isn’t a problem. Now they’re beginning to see how much of a difference it’ll make for transplant patients.